Induction and inhibition of the allantoin permease in Saccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Induction of the allantoin degradative enzymes in Saccharomyces cerevisiae by the last intermediate of the pathway.
Saccharomyces cerevisiae can degrade allantoin in five steps to glyoxylate, ammonia, and "CO(2)." We previously demonstrated that synthesis of the urea carboxylase-allophanate hydrolase multienzyme complex is contingent upon the presence of allophanic acid, the product of the urea carboxylase reaction. Since these enzymes catalyze the last two reactions of allantoin degradation, experiments wer...
متن کاملNitrogen repression of the allantoin degradative enzymes in Saccharomyces cerevisiae.
Saccharomyces cerevisiae can utilize allantoin as a sole nitrogen source by degrading it to ammonia, "CO(2)," and glyoxylate. We have previously shown that synthesis of the allantoin degradative enzymes is contingent upon the presence of allophanate, the last intermediate in the pathway. The reported repression of arginase by ammonia prompted us to ascertain whether or not the allantoin degrada...
متن کاملThe MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
In response to nitrogen starvation, diploid cells of the budding yeast Saccharomyces cerevisiae differentiate into a filamentous, pseudohyphal growth form. This dimorphic transition is regulated by the Galpha protein GPA2, by RAS2, and by elements of the pheromone-responsive MAP kinase cascade, yet the mechanisms by which nitrogen starvation is sensed remain unclear. We have found that MEP2, a ...
متن کاملNitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae.
Addition of ammonium ions to yeast cells growing on proline as the sole nitrogen source induces rapid inactivation and degradation of the general amino acid permease Gap1 through a process requiring the Npi1/Rsp5 ubiquitin (Ub) ligase. In this study, we show that NH4+ induces endocytosis of Gap1, which is then delivered into the vacuole where it is degraded. This down-regulation is accompanied ...
متن کاملThe ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease.
The purpose of this work was to identify the function of an open reading frame called YBL042, found during the systematic sequencing of Saccharomyces cerevisiae's chromosome II. The YBL042 gene product shows 70% similarity with the uracil permease and the allantoin permease encoded by FUR4 and DAL4, respectively. The mutation constructed by disruption of this ORF is allelic to the FUI1 gene pre...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1978
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.135.2.498-510.1978